Correlation Between ISAba1 Upstream ampC Gene and Resistance to Cefotaxime in Acinetobacter baumannii: A Serious Threat to Nosocomial Infections
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چکیده
منابع مشابه
correlation between isaba1 upstream ampc gene and resistance to cefotaxime in acinetobacter baumannii: a serious threat to nosocomial infections
conclusions isaba1 has become an important factor in a. baumannii’s resistance to cefotaxime. results isaba1 located upstream of blaampc was found in 24 (48%) of the a. baumannii isolates. in all of the studied isolates that had isampc, the mic for cefotaxime was 64 - 256 μg/ml. based on the rep-pcr patterns among the resistant isolates, the highest number of isampc positive isolates belonged t...
متن کاملISAba1 targets a specific position upstream of the intrinsic ampC gene of Acinetobacter baumannii leading to cephalosporin resistance.
Sir, Resistance to third-generation cephalosporins such as ceftazidime and cefotaxime in Acinetobacter baumannii is often due to increased expression of an intrinsic ampC gene. Expression increases when the ISAba1 insertion sequence (IS) is present in the appropriate orientation upstream of the ampC gene, providing an outward-facing promoter that appears to be stronger than the intrinsic promot...
متن کاملTn6168, a transposon carrying an ISAba1-activated ampC gene and conferring cephalosporin resistance in Acinetobacter baumannii.
OBJECTIVES To explore the cause of third-generation cephalosporin resistance in Australian Acinetobacter baumannii isolates belonging to global clone 1 (GC1). METHODS GC1 isolates from Australia were tested for resistance to ceftazidime and cefotaxime using disc diffusion and MICs. PCR was used to determine the context of ISAba1-ampC configurations and amplicons were sequenced. The level of t...
متن کاملAcinetobacter baumannii nosocomial infections.
UNLABELLED Nosocomial infections caused by strains Acinetobacter baumannii strands are a growing clinical problem. The occurrence of multidrug-resistant strands is observed and that limits the ways of therapy considerably. The aim of the study was to determine the rate of infection and susceptibility spectrum of the species Acinetobacter baumannii isolated from patients treated at Maria Skłodow...
متن کاملNosocomial Acinetobacter baumannii Infections and Changing Antibiotic Resistance
OBJECTIVES In the intensive care setting, Acinetobacter baumannii causes ventilator-associated pneumonia and other nosocomial infections that are difficult to treat. Objective of this study was to investigate nosocomial A. baumannii infections and its changing antibiotic resistance. METHODS A total of 56 patients diagnosed with A.baumannii infections between January 2009 and December 2011 wer...
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ژورنال
عنوان ژورنال: Avicenna Journal of Clinical Microbiology and Infection
سال: 2016
ISSN: 2383-0298,2383-0301
DOI: 10.17795/ajcmi-32417